| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a9a02b9e7076ff72115c32f83d71f99a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-185 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-0033
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-555 |
| filingDate |
2021-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b53244a1132b316de83a98f36a7a7731
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3aae12eadc56ad815754d9a79d42239
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85415ca5b1ce91d0feba89781b163768
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ce104267cd6fc856fe4c64cf1f37811
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e2840fcf5cb2f4f77cd9ff9227b492f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12b89ef963660ee0502fd3685342d0d8 |
| publicationDate |
2022-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114057777-A |
| titleOfInvention |
A kind of β-carboline derivative and its preparation method and application |
| abstract |
The invention discloses a β-carboline derivative and a preparation method and application thereof. The above-mentioned β-carboline derivative is used to prepare an iridium complex; a new iridium complex is prepared by using the β-carboline derivative of the present invention The complex is rapidly absorbed by cells and has obvious targeting effect on tumor cell mitochondria, which in turn causes mitochondrial morphological changes and induces mitochondrial dysfunction, such as affecting mitochondrial membrane potential and leading to increased reactive oxygen species. It also exhibited phototoxicity to cancer cells, with the compounds showing increased toxicity to tumor cells after light exposure compared to the dark. Finally, it exerts anti-tumor effect by inducing apoptosis of cells. |
| priorityDate |
2021-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |