| abstract |
The present invention relates to antibody-drug conjugates and methods. The present invention relates to an antibody-drug conjugate compound of formula I: Ab-(L-D) p I wherein one or more maytansinoid drug moieties (D) are covalently linked to the antibody (Ab) through L, so The antibody (Ab) binds to the ErbB receptor, or to one or more tumor-associated antigens or cell surface receptors. These compounds are useful in methods of diagnosis or treatment of cancer, as well as other diseases and disorders. |