http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114053418-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d94573ab2c57e8b193f3a22accddf9fe |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-69 |
| filingDate | 2021-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0df1f73a281b20072aad650ae9feed81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3e58e8126dc1f3a93f923f7368ffe9c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_146273455a5ee5dced0165100799d437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2ea6e888c0feaa2e659a95a55e8b734 |
| publicationDate | 2022-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114053418-A |
| titleOfInvention | A copper-coordinated nanocarrier and its preparation method and its application as a tumor chemotherapy drug |
| abstract | The invention discloses a copper-coordinated nanoparticle, a preparation method thereof, and an application as a tumor chemotherapy drug. Copper ions are used as metal ion nodes to coordinate with organic ligands and stabilized by lipids to prepare copper-coordinated nanocores. The phospholipid bilayer is encapsulated in the outer layer, and the hydrophobic drugs responsive to the tumor microenvironment are encapsulated in the lipid layer to form nanoparticles with uniform particle size. The method has the advantages of simple operation, short time consumption and mild reaction conditions; the material has good biocompatibility and high safety. After intravenous injection, the particles respond to the tumor microenvironment, such as high levels of glutathione (GSH) or reactive oxygen species (ROS) in tumor cells, or high levels of enzymes such as matrix metalloproteinases. The drugs in the lipid layer can break bonds in response to the tumor microenvironment, compete for copper in the copper carrier, disintegrate the nanoparticles, form complexes and release organic ligand drugs, which work together on the tumor for synergistic chemotherapy, enhancing the therapeutic effect at the same time. , reducing the safety of normal tissue. |
| priorityDate | 2021-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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