abstract |
The invention provides an application of COL4A4 gene as a therapeutic target of acute ischemic stroke, in particular to the preparation of molecular targeted drugs for preventing and/or treating acute ischemic stroke, and the preparation of acute ischemic stroke Neuroprotective agent. The COL4A4 of the present invention is highly conserved in human-derived or mouse-derived species. Through knockdown or overexpression experiments of COL4A4, it is confirmed that COL4A4 can be used as a target for the treatment of acute ischemic stroke, and can be used to prepare molecular targeted drugs to reduce deficiency Hypoxic neuronal apoptosis. The invention provides a new target for developing neuroprotective drugs for acute ischemic stroke. |