| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c13f0402219c2a116474be2bfca70c5 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-552 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-866
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-11 |
| filingDate |
2021-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7dca4926f1be858367ecadb19dc3f17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5d1ba2423d3b7d8e7b205f22b5b8216
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4beb29e44c05ecf10262b1692db7a0d8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_100d8b6f7e78ac3859f997ce9eec1405
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25dfc0367d2ba1de43e8f745a5f3c7fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f76410826f1c984d01aa607aaa391b65 |
| publicationDate |
2022-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114031674-A |
| titleOfInvention |
A kind of H7N9 avian influenza virus HA protein with enhanced thermal stability and preparation method and application thereof |
| abstract |
The present invention provides an H7N9 avian influenza virus HA protein with enhanced thermal stability, and the amino acid sequence of the H7N9 avian influenza virus HA protein with enhanced thermal stability is shown in SEQ ID NO: 2. Compared with the wild-type HA protein, the H7N9 avian influenza virus HA protein of the present invention has stronger thermal stability and immunogenicity. After the H7N9 avian influenza virus HA protein of the present invention is combined with SEPPIC MONTANIDE TM ISA 71 VG to immunize SPF chickens, compared with the wild-type HA protein, the body can stimulate the body to produce a higher level of HI antibody more quickly, and can provide antibodies against heterologous H7N9 poultry Complete clinical protection from lethal challenge with influenza virus while reducing the amount of flock shed after challenge. |
| priorityDate |
2021-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |