http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114028583-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53b4d53983adbf56dd0e7d0bf96f8ce5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6923 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6929 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 |
| filingDate | 2021-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7807b99a82e7a08e9db2447a8a07176 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ff084b05668b653315a94d6a78b58e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be59d2a3aa421021c747a1b134ed9040 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_776f6cfdbed7ecd7bc20ef273cca1a22 |
| publicationDate | 2022-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114028583-A |
| titleOfInvention | Degradable silicon-based support material based on ZnO composite mesoporous silica and its preparation method and application |
| abstract | The present invention provides a degradable silicon-based carrier material based on ZnO composite mesoporous silica. The carrier material is a ZnO composite mesoporous silica nanoparticle whose surface is grafted and blocked by glutathione-responsive functional groups. , ZnO composite mesoporous silica nanoparticles are mesoporous silica loaded with ZnO quantum dots, the blocking valve is polyethylene glycol-folic acid, and the blocking valve blocks the ZnO composite mesoporous silica mesopores The orifice of silicon nanoparticles, the disulfide bond in the carrier material can be cut off by glutathione, after the disulfide bond is cut off, the blocking valve falls off and the pores of the ZnO composite mesoporous silica mesoporous silicon nanoparticles are opened. At the same time, the ZnO quantum dots in the carrier material can be dissolved in an acidic environment to promote the degradation of the carrier material. The invention endows the silicon-based carrier material with good biodegradability, excellent targeting ability and drug controlled release performance. The invention also provides a preparation method of the carrier material and its application as a drug carrier. |
| priorityDate | 2021-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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