http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114026647-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2817954cd008bcd609a4c4eb49050be http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac8640423bf7e37778b31f0dc412dce8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d3b0bb8c2b7c35b9186ae51aceaae04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B30-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B50-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B30-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B20-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B50-10 |
| filingDate | 2020-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ced9cdef8f26a1c34356f2f1487e8937 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47502c1dab0b9a12fb96b099ff9d2e9c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74023028c4f0c586f99f8ad8f5f28c6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac7ceec6f039997fc3064c17dcf69431 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b33117e8ee8524d8306a29ecdb537490 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_728bc2996bd2d078fece30124a5ae1b9 |
| publicationDate | 2022-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114026647-A |
| titleOfInvention | Comprehensive detection of unicellular genetic structural variation |
| abstract | The present invention provides a method for detecting Structural Variation (SV) within the genome of a single cell or a population of single cells by integrating three layers of information of sequencing read depth, read strand orientation, and haplotype phasing. The methods of the invention can detect deletions, duplications, polyploids, translocations, inversions, and loss of copy number neutral heterozygosity (CNN-LOH), among others. The method of the invention can fully perform comprehensive karyotype analysis on the genome, and can be applied to research and clinical methods. For example, the methods of the invention can be used to analyze a cell sample from a patient for diagnosis or to aid in diagnosis, to detect embryo abnormalities in reproductive medicine, or to quality control genetically engineered cells in cell therapy-based therapeutic approaches, such as in adoptive T cell therapy, and the like. The methods of the invention may further be applied in research to decipher cell models (cell lines), karyotypes of patient samples, or to further reveal genetic and mechanical pathways leading to the production of any SV within a genome. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116030892-A |
| priorityDate | 2019-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.