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filingDate 2021-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_350d59850a72170addc2bbd455996c7b
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publicationDate 2022-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114014893-A
titleOfInvention Selenium-containing iron group metal complex and preparation method and application thereof
abstract The invention discloses a selenium-containing iron group metal complex and a preparation method and application thereof, wherein selenadiazole (PhenSe for short) is mixed with ethylene glycol, and (NH) is added after ultrasonic homogenization 4 ) 2 OsCl 6 Refluxing at high temperature, cooling, adding excessive sodium chlorate, adding water, precipitating solid, centrifuging to remove supernatant to obtain black brown solid as target complex Os (PhenSe) 3 (ClO 4 ) 2 (ii) a Mixing PhenSe with ethanol, ultrasonically stirring to obtain suspension, and adding RuCl 3 ยท3H 2 Mixing O powder in ethanol, adding the suspension, refluxing at high temperature, cooling, standing, and collecting the supernatantOrange yellow, taking the supernatant, recrystallizing, separating out orange yellow crystal, and collecting as target complex Ru (Phense) 3 Cl 2 . By using a ligand as a contrast, the ruthenium and osmium complexes using the carbon diazole as the ligand are synthesized by a similar method. By introducing selenium, the invention obviously enhances the growth inhibition effect of the osmium complex on all malignant breast cancers and also enhances the anti-tumor activity of the ruthenium complex.
priorityDate 2021-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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