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filingDate 2021-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114010842-B
titleOfInvention Microfluidic 3D printing bionic skin scaffold based on polyhydroxyalkanoate and preparation method thereof
abstract The invention provides a microfluidic 3D printing bionic skin support based on polyhydroxyalkanoate and a preparation method thereof. The method combines a microfluidic chip and 3D printing technology to generate a continuous stable solution containing polyhydroxyalkanoate The liquid flow is dripped into the ethanol collection phase, and the microfiber scaffold with uniform size is formed by the diffusion and volatilization of the organic solvent in the ethanol aqueous solution. The microfiber scaffold prepared by the invention has a hierarchical porous and extracellular matrix-like structure, and can realize precise adjustment of the diameter of the microfiber by changing the preparation conditions (the flow rate of the liquid flow in the microfluidic chip or the moving speed of the nozzle of the 3D printer). The method is simple and easy to implement, and the shape of the stent can be adjusted through the preset 3D model pattern. The biomimetic structure polyhydroxyalkanoate scaffold prepared by the invention can effectively load a variety of active cells to realize double-sided heterosexuality, so as to realize the repair and regeneration of complex skin wounds.
priorityDate 2021-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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