| abstract |
The invention discloses a method for preparing amide derivatives by direct amination of alkyl C-H bonds under catalysis of nickel promoted by visible light. The invention uses substituted oxazoline ketone as an amination reagent, has cheap and easily obtained raw materials and wider substrate applicability, and can be used for post-modification reaction for introducing amide groups into bioactive molecules. In addition, the method disclosed by the invention has the advantages of mild reaction conditions, high yield of target products, small pollution, simple reaction operation and post-treatment process, and suitability for industrial production. |