| abstract |
The invention belongs to the technical field of material synthesis and biomedicine, and in particular relates to a multiple-response drug controlled release system, a preparation method and an application. The method comprises the steps of: preparing an aminated silica/gold nanorod solution, centrifuging, dispersing the aminated silica/gold nanorod in an acidic methanol solution, refluxing, and centrifuging to obtain the aminated mesoporous silica/gold nanorod ; Disperse the aminated mesoporous silica/gold nanorods and the drug into water, stir, and wash with centrifugal water to obtain the drug/aminated mesoporous silica/gold nanorods; disperse the drug/aminated mesoporous silica/gold The nanorods are added to the solution of sodium hyaluronate and reacted under stirring to obtain a multi-response drug controlled release system. The multi-response drug controlled release system prepared by the invention can simultaneously release the drug in response to photothermal, pH and hyaluronidase stimulation, and has high biocompatibility and good tumor targeting. |