abstract |
The present invention relates to single-stranded RNA editing antisense oligonucleotides (AONs) for binding to target RNA molecules, deaminating at least one target adenosine present in the target RNA molecules and recruiting ADAR2 in cells, preferably human cells An enzyme to deaminate at least one target adenosine in a target RNA molecule. AONs according to the present invention include a cytidine analog at a position opposite the target adenosine, wherein the cytidine analog acts as an H-bond donor at the N3 site for more efficient RNA editing. |