| abstract |
The present invention relates to an antibody, which specifically binds to the tyrosine protein kinase receptor TIE-2 (TIE2), thereby having the functions of normalizing and stabilizing blood vessels through receptor phosphorylation, and relates to: an anti-TIE2 antibody; A nucleic acid encoding the same; a vector comprising the nucleic acid; a cell transformed with the vector; a method for producing an antibody; an agent for stabilizing blood vessels and a composition for treating angiogenesis-related diseases, both comprising the antibody and compositions for co-administration with pharmaceutical compositions for tumor or cancer treatment and compositions other than antibodies that bind to TIE2. |