http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113984729-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-6439 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0054 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y30-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6456 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0034 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y30-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00 |
| filingDate | 2021-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113984729-B |
| titleOfInvention | Hypoxia-responsive ratiometric probe synthesis method and its application |
| abstract | The invention belongs to the field of biological analysis, and specifically relates to a hypoxia-responsive ratio probe synthesis method and application thereof, aiming at solving the problem that the existing in vivo hypoxia imaging can only achieve qualitative hypoxia detection, but cannot be accurate and reliable. the assessment of the degree of hypoxia. The invention includes: using anthocyanin fluorescent dye Cy5-NHS to modify the fifth-generation polyamidoamine dendrimer PAMAMG5 to obtain PG5-Cy5; encapsulating the nitroreductase-responsive fluorescent molecule Cy7-NO 2 in the PG5- The hydrophobic cavity of Cy5 forms Cy7-NO 2 /PG5-Cy5; the tumor recognition group is selected from oligohyaluronic acid LWHA and modified on the outer layer of Cy7-NO 2 /PG5-Cy5 to synthesize Cy7-NO 2 /PG5-Cy5@ LWHA. The hypoxia-responsive ratio probe prepared by the invention has the characteristics of high sensitivity, high specificity and long circulation in vivo. |
| priorityDate | 2021-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.