http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113975254-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d890d1cd80add0e6feb16600c49e2a7a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-10 |
| filingDate | 2021-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bf1a8d62260421bf3eff3a6df8a8a03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e291b915289239b6f5c55e881ea19d14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0531c0c7cf581a6e0c075ab8cbfdf06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6608f956c89ee354644160357662f0f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f034c187aee373e888cf06e9482a08e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95760174b01e72db27be08935d262cc1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c1138ce1fa8c673053b4db76593786d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97aaecb008e2f45c69faa555765f7384 |
| publicationDate | 2022-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113975254-A |
| titleOfInvention | Application of DMSO in the preparation of medicines for alleviating ionizing radiation-induced damage to male reproductive system |
| abstract | The invention provides the application of DMSO in the preparation of a medicine for alleviating ionizing radiation-induced damage to the male reproductive system. By constructing a mouse radiation testicular injury model, the present invention finds that DMSO can significantly increase the sperm count of mice irradiated with 5Gy, reduce the sperm deformity rate, and promote the recovery of reproductive ability of male mice after irradiation. Mechanistically, DMSO reduces the level of oxidative stress in spermatogenic cells after irradiation, inhibits the apoptosis of spermatogenic cells, and promotes the proliferation of spermatogenic cells. Further, DMSO can also alleviate spermatogonial stem cells and spermatogonia by reducing cellular DNA damage. Radiation damage to cells, promoting rapid recovery of spermatogenesis after irradiation. DMSO is expected to be a very promising radioprotectant for radiation-induced damage to the male reproductive system. |
| priorityDate | 2021-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 286.