http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113970607-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_689c96ab2f2a56bdd3bfbed413aebc01 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2030-047 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-8634 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 |
| filingDate | 2021-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d4da1d9fc86f845341fbed38eb5d542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ecdafd94037c62bef7332d16af68f81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48df3a5dc63d9c8d28987ac10afd22c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed17a77dcbe56ef912f9f0a55ba82039 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_336375d8b24cc6c30fd7fc36dc99700a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46b47807b933b01d173dc70a410323f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3aba38e3e884bb1219aa919818a04d3 |
| publicationDate | 2022-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113970607-A |
| titleOfInvention | Method for detecting related substances in balsalazide disodium capsule |
| abstract | The invention relates to the technical field of medicine quality detection, and particularly discloses a high performance liquid chromatography analysis method for related substances in balsalazide disodium capsules. The method adopts a C18 chromatographic column, takes water as a diluent to prepare a sample to be detected, and uses an ultraviolet detector to carry out liquid chromatography quantitative analysis. The chromatographic conditions are as follows: the column temperature is 40-50 ℃, the detection wavelength is 235-245 nm, the flow rate is 0.8-1.2 mL/min, an ammonium acetate solution with the pH value of 6.5-7.5 is used as a mobile phase A, acetonitrile is used as a mobile phase B, and a gradient elution program is established, wherein the concentration of the ammonium acetate solution is 0.02-0.05 mol/L, and the pH regulator is an ammonia solution. Compared with the United states pharmacopoeia and the current domestic standard, the method increases the research on the key impurity biphenyl azo salicylic acid, has the advantages of more detectable impurities, good peak shape and high separation degree, and improves the accuracy of impurity detection and the quality controllability of products. |
| priorityDate | 2021-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.