http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113968826-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d58488a8db3e37c07e675d946c864f0e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-36 |
| filingDate | 2021-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e0c1f9d1b10f5221b46d77d825be91f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65c915e8b8a66ea6fa61991d86d990cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b252c52895d78bb5dbf0e964e57fb533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a5a7ddfa332497d6577b04dad04f13d |
| publicationDate | 2022-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113968826-A |
| titleOfInvention | Preparation method of impurity F and impurity G of iodixanol |
| abstract | The invention discloses a preparation method of an impurity F and an impurity G of iodixanol, which uses 5-nitroisophthalic acid dimethyl ester as a starting raw material to generate the impurity F of iodixanol through condensation, reduction, acetylation, hydrolysis, dimerization, iodination and condensation; after iodixanol impurity F is subjected to acetylation and hydrolysis reaction, iodixanol impurity G is generated; the iodixanol impurities F and G are easily degraded in the stability lofting process of an iodixanol raw material medicament and a preparation, are difficult to prepare, purify and separate, and have great influence on the quality and the drug effect of the raw material medicament; at present, the related preparation methods of iodixanol impurity F and impurity G are not available in the prior art, and the invention fills the blank of the preparation methods of iodixanol impurity F and impurity G. |
| priorityDate | 2021-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.