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filingDate 2021-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2022-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-113960208-A
titleOfInvention Method for measuring content of active ingredients in preparation containing apremilast
abstract The invention belongs to the technical field of drug analysis and detection, and particularly relates to a method for determining the content of active ingredients in an apremilast-containing preparation, which is to determine by adopting a high performance liquid chromatography, wherein the specific liquid phase conditions are as follows: shimadzu SPD-20A; a chromatographic column: hypersil BDS reverse C18 column (5 μm,4.6 mm. times.250 mm); ultraviolet detection wavelength is 230 nm; column temperature: room temperature; mobile phase methanol to water (pH =3.5 phosphoric acid solution) =54: 46; sample introduction amount: 20 ul; flow rate: 0.8 ml/min. The HPLC detection method has strong specificity, and the auxiliary materials do not interfere with the detection of Apremilast; the method can conveniently, accurately and reliably measure the content of the apremilast and truly reflect the quality of the product.
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