http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113956332-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff9a8a894ec90fe1c7e5ad02149075d3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6486 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57446 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 |
| filingDate | 2021-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8de64da5f653e4a5ee25adb0d0211f52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56cfd706e0a859c8ba742c983e3b38e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_381d2f05bfaaab3ceb941f7ae89ad7e8 |
| publicationDate | 2022-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113956332-A |
| titleOfInvention | A near-infrared probe that binds to early gastric cancer with high affinity and its preparation method |
| abstract | The invention discloses a near-infrared probe that binds to early gastric cancer with high affinity and a preparation method thereof. The preparation method includes S1. First, construct a polypeptide SNF and its three-dimensional structure, and obtain the extracellular three-dimensional structure of EpCAM, a binding receptor of the polypeptide SNF, The three-dimensional simulation of the binding site of SNF and EpCAM and the modification of SNF were carried out, and the candidate optimized short peptides were obtained by screening; S2. Fluorescence staining and affinity comparison of the gastric cancer cell line SGC7901 cells with high expression of the optimized peptide and EpCAM; S3. Preparation of probes : The optimal short peptide screened in step S2 is linked to CY5.5 to synthesize a near-infrared probe; a fluorescent probe that can specifically target early gastric cancer is obtained. The near-infrared probe has good Good features include stability, low immunogenicity, low production cost, and rapid imaging after administration. |
| priorityDate | 2021-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.