| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d890ad239375a780e6827d3407f15ef3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y405-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-02 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 |
| filingDate |
2021-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_180921320a8c95623db52f1e54d793eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8bf23c2bbddc74a8e7cf7323a7acb37e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da35a7e35fc5021145c9b47e86d64368 |
| publicationDate |
2022-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113930415-A |
| titleOfInvention |
Halogen alcohol dehalogenase mutant and application thereof |
| abstract |
The invention discloses a halohydrin dehalogenase mutant and application thereof in synthesizing a key chiral epoxy intermediate of an antifungal drug. The invention relates to the field of genetic engineering and enzyme engineering, in particular to a stereoselectively overturned halohydrin dehalogenase mutant N176G, the corresponding amino acid sequence of which is shown as SEQ ID No. 4. The halohydrin dehalogenase mutant can be applied to asymmetric dehalogenation of a catalytic compound I to synthesize a chiral epoxide II, the separation yield is 80%, and the optical purity is as high as 98% ee. |
| priorityDate |
2021-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |