| abstract |
The invention discloses an anti-degradation gelatin microsphere, an artificial liver model, a construction method and an application thereof. The invention takes the anti-degradation gelatin microspheres as a cell carrier, inoculates vascular endothelial cells and liver cell poles on the surface of the cell carrier, and forms the artificial liver model through spontaneous bonding and assembling, thereby not only improving the anti-degradation property of the artificial liver model, but also ensuring the obtained artificial liver model to have high vascularization degree, being beneficial to liver function expression and long-term in vitro application of the artificial liver model, and being used for liquor quality identification and the evaluation of the treatment effect of alcoholic liver disease treatment drugs. |