http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113929592-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d0116a50f927355901ae34b0aae45096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f04e30a60ae408a7e9d832b566b387c1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-46 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2021-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_535cf09762d6226019df8a7b08d5ee7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_026d4ee407c9f809ea5853ebc3f187f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2fd5f711b141df1b5bb70283329c4de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d45fd847a38d6754a71d4e8d758250d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d24d4081269157b2c0c4cd71e748105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2235c3261b693ede0898f9a301d1855d |
| publicationDate | 2022-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113929592-A |
| titleOfInvention | A kind of preparation method of doxycycline intermediate |
| abstract | The invention relates to the technical field of veterinary drugs, in particular to a method for preparing a doxycycline intermediate, comprising the following steps: (1) mixing metacycline p-toluenesulfonate and absolute ethanol in proportion, and then adding concentrated Hydrochloric acid, the temperature of the reaction system after stirring and mixing is controlled at 10-35°C; (2) Zinc borohydride solution is added dropwise to the reaction system in step (1), and the heat preservation reaction time is controlled at 2-5h, and the obtained feed liquid is used for later use (3) under the condition of 20-30 ℃, the sulfosalicylic acid aqueous solution and the feed liquid in the step (2) are added dropwise to the feed liquid of the step (2) according to the mass ratio of 0.7-1.5:1, After 4-6 hours of incubation reaction, the temperature was lowered to 0-10 °C, and the doxycycline sulfosalicylate was obtained by filtration. By using the preparation method, the conversion rate and selectivity of raw materials and the yield of doxycycline p-toluenesulfonate are improved, and the reduction cost and the safety risk in the reaction process are reduced. |
| priorityDate | 2021-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.