http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113912554-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6ccaf8a3d3fdeb707e78db70f8f96ce7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 |
| filingDate | 2021-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a10a1553560af059eaf2ceca1ab51d5a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5ec9c9310b773dee52bf44f4996c3eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69454c32335d3570442a6f385f5bcabb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f0d3a67d3e466478891873cd310a672 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cf726f3ee22d73daca9d919b92c810a |
| publicationDate | 2022-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113912554-A |
| titleOfInvention | A kind of synthesis and refining process of erlotinib hydrochloride |
| abstract | The erlotinib hydrochloride synthesis and purification process of the present invention comprises the following steps: 1. using 6,7-bis(2-methoxyethoxy)-quinazoline-4 ketone as a starting material, chlorination to obtain an intermediate (1): 4-chloro-6,7-two-(2-methoxyethoxy)-quinazoline; 2. the intermediate (1) is docked with 3-amino phenylacetylene, and the intermediate is free and refined through aftertreatment Body (2): N-(3-acetylene phenyl)-6,7-bis(2-methoxyethoxy)-4-quinolinamine; 3. make intermediate (2) salify with hydrogen chloride, and obtain Finished product erlotinib hydrochloride. The synthesis and purification process of the invention has the advantages of easy availability of raw materials, mild reaction conditions, avoiding the use of multiple types of highly toxic solvents, simple operation steps and suitable for industrial production, and the total yield of the products obtained by the process is higher, and the quality index is better than domestic standard. |
| priorityDate | 2021-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.