| abstract |
The invention discloses a method for synthesizing 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid. The method comprises cyclopropanecarboxylic acid and fluorine Under the catalysis of a phase transfer catalyst, potassium chloride undergoes a fluorination reaction to generate 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxygen-3-quinolinecarboxylic acid, wherein the phase-transfer catalyst is Quaternary ammonium salt catalyst. The invention overcomes the defects of the prior art, simplifies the synthesis process, shortens the production time, improves the yield, reduces the production cost, and is suitable for industrial production. |