| abstract |
Certain substances (such as macromolecules) that normally cannot cross the blood-brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected such that the application of the alternating electric field raises the blood-brain barrier of permeability. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (eg, 100 kHz). Once the permeability of the blood-brain barrier is increased, substances are able to cross the blood-brain barrier. |