| abstract |
The invention discloses a metal peroxide composite injectable hydrogel and a preparation method and application thereof. In the present invention, the modified macromolecular polymer, metal peroxide and peroxidase are dissolved in a solvent, and the hydrogel is prepared by mixing and standing; wherein, the modified macromolecular polymer is a high molecular weight grafted phenolic hydroxyl group. molecular polymers. In the present invention, the hydrogel is prepared by inducing the rapid cross-linking of the modified macromolecular polymer by metal peroxide under the action of peroxidase, and the hydrogel has good photothermal properties, antibacterial properties, tissue adhesion, promoting Bone function, shape adaptability and injectability can be well adapted to irregular bone defect areas, and through the synergistic effect of multiple functions, it can be used for the repair of postoperative tumor defects and effectively prevent tumor recurrence and reduce implant material infection. possibility. |