http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113893346-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025 |
| filingDate | 2020-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113893346-B |
| titleOfInvention | Use of GCS inhibitors in the preparation of drugs for the treatment of cocaine addiction |
| abstract | The invention discloses the use of a GCS inhibitor in the preparation of a drug for treating cocaine addiction, and belongs to the field of drugs for detoxification. The present invention proves through experiments that the GCS inhibitor can specifically reduce the content of glucosylceramide sphingolipids in the nucleus accumbens brain region, reduce the number of dendritic branches and the density of dendritic spines, and effectively inhibit the behavioral effects of cocaine on mice (behavioral effects) sensitization, reward effects, and behavioral effects of autonomous administration). The use of the GCS inhibitor in the preparation of drugs for treating cocaine addiction has good application prospects. |
| priorityDate | 2020-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 111.