| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d94573ab2c57e8b193f3a22accddf9fe |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y603-02019 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate |
2021-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ebfa185e50bb85b0a038a337cf752eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_363f1f2eb5ee2e6033e71b3edcfb72e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b21ce48a405258f833de7d5c25bcda1b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d36d7d6788fcc2c903546d1aab2c5025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5394e5ffecf6ec4675bcf645646639da
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3c6b26bfe1394febdb21626f2b32863
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa657ba03a2d299135921171a032e2ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b0e074fcc556230fc18935185043f2f |
| publicationDate |
2022-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113893337-A |
| titleOfInvention |
Application of DTX2 protein in the preparation of preparations for regulating telomerase activity |
| abstract |
The invention discloses the application of DTX2 protein in preparing preparations for regulating telomerase activity. The present invention finds that DTX2 is a new factor that activates telomerase. DTX2 protein is involved in regulating the expression of the catalytic subunit hTERT of telomerase and the regulation of telomere length, and its expression level is positively correlated with the expression level of hTERT and telomerase activity. Relatedly, interfering the expression of DTX2 protein or knocking out DTX2 can significantly reduce the expression and telomerase activity of the catalytic subunit hTERT in cells. DTX2 protein is a positive regulator of telomerase, which can be used to prepare preparations that positively regulate the totipotency of stem cells, and DTX2 protein inhibitors can also be used to prepare telomerase-positive tumor therapeutic drugs. DTX2 protein is of great significance for the clinical application of stem cells and the treatment of malignant tumors in the future. |
| priorityDate |
2021-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |