| abstract |
The invention discloses a microsphere composition for injection, comprising: a) 10% to 97% by weight of microsphere A, said microsphere A containing polylactide glycolide cosmetic and/or medicinal components; b) 1% to 40% by weight of microspheres B, said microspheres B contain a cross-linking agent and a matrix material with a melting point of 21-45°C, said microspheres B melt at body temperature and release a cross-linking agent to make hyaluronic acid or its The salt undergoes a cross-linking reaction, c) 2% to 50% by weight of hyaluronic acid or its salt. The method of use of the present invention is to fully mix microsphere A, microsphere B, hyaluronic acid (salt) with isotonic saline solution or phosphate buffer solution to obtain a suspension with a certain viscosity that can be injected smoothly, inject When entering human tissue, microsphere B melts at body temperature and releases a cross-linking agent. After hyaluronic acid (salt) is cross-linked with the cross-linking agent, an elastomer with higher mechanical strength can be formed, which can not only perform lubrication and filling more stably action, but also the sustained release of cosmetic and/or medicinal active ingredients for a double effect. |