| abstract |
The present invention relates to a lipid-encapsulated albumin-binding chemotherapeutic nanoparticle and a preparation method and application thereof. In the present invention, lipid molecules are wrapped on the surface of albumin-binding chemotherapeutic drug nanoparticles, and further mixed with genes to prepare lipid albumin nanoparticles carrying genes and chemotherapeutic drugs; or albumin is made into nanoparticles, and then Lipid molecules are wrapped on the surface and further mixed with genes to obtain lipid albumin nanoparticles that can be used for cell transfection or gene therapy. The preparation method is environmentally friendly, has good repeatability, is simple and convenient, and has high yield. The prepared nanoparticles have regular morphology and uniform particle size, and the loaded gene has very good transfection efficiency. In the field of tumor treatment, especially drug resistance The field of tumor therapy has broad application prospects. |