abstract |
The present invention relates to the field of biotechnology, and in particular, provides a DNA molecule, a DNA vaccine and an application that encode an antigen of a SARS-COV-2 virus B.1.617.2 mutant strain. The nucleic acid sequence of SEQ ID NO: 1 provided by the present invention can be efficiently transcribed and expressed in the eukaryotic expression system, and has immunogenicity, which is manifested in humoral immunity and cellular immune response, and the nucleic acid vaccine as an active ingredient also has good of immunogenicity. |