http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113861211-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4f4a4214511b480e308054236dd22b4d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 |
| filingDate | 2021-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9dd36f28df5f31622537712fdccb4284 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20dc9fa11863fbe936a407dfabf1defa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21c346b96b39570870aad46009cf686d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4832ac7a59294cc499cc3c8ff8eb351e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75e8554173534c4bd25bf5b681d8840c |
| publicationDate | 2021-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113861211-A |
| titleOfInvention | The preparation technology of isosorbide dinitrate |
| abstract | The invention belongs to the technical field of drug synthesis, and in particular relates to a preparation process of isosorbide dinitrate. The preparation process is as follows: after the sorbitol liquid is evaporated under normal pressure to remove water, dehydrated into a ring under the action of sulfuric acid to obtain sorbitan, and reacted with nitric acid to obtain isosorbide nitrate. In the preparation process of isosorbide dinitrate of the present invention, when dehydrating in sorbitol, the dehydration temperature is controlled to make the dehydration reaction of sorbitol complete; when collecting fractions, the vacuum degree is controlled to reduce the temperature range for collecting fractions , which can improve the quality of sorbitan; in the synthesis and preparation of crude products, control the dropping speed of ice decomposition and the stirring speed of the ice decomposition kettle, so that the ice desorption and crystallization are uniform, and impurities are not easily precipitated, thereby improving the quality and yield of crude products. |
| priorityDate | 2021-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.