| abstract |
The invention discloses a method for preparing an arylcyclopropane compound, which uses 1.0eq of phenylacetonitrile and 1.1eq of 1-bromo-2-chloroethane as starting materials, and N,N-dimethylacetamide as a solvent, The amount of solvent was 10V, 2.5eq of sodium hydride was added, the reaction system was protected with an inert gas and the temperature was controlled at -15±5°C during the addition, and the reaction was performed at room temperature for 5 to 16 hours, and the obtained crude product was separated and purified by column. The preparation method of the arylcyclopropane compound of the present invention can easily obtain the arylcyclopropane compound, and the operation of the reaction is simple and convenient, the scope of application is wider than that of the traditional synthesis method, and the reaction conditions are mild, and the synthesis of the subsequent derivatives is also provided. more convenient route. |