| abstract |
The present invention relates to a DNA construct, and a strain into which a recombinant vector comprising the DNA construct has been introduced. The DNA constructs of the present invention allow the expression levels of genes operably linked downstream of the first and second promoters to be balanced in the host strain or cell so that cancer diagnosis and treatment can be performed simultaneously. In addition, the DNA construct of the present invention does not allow the expression of anti-cancer proteins and reporter proteins at all in the absence of doxycycline, thus it can regulate the use of doxycycline, thereby allowing the use of anti-cancer proteins for cancer therapy At the same time, it can realize real-time monitoring of cancer scale according to the expression level of reporter protein. |