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filingDate 2021-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32e0656dbc6e91bd96263fe25acd6df7
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publicationDate 2021-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-113846133-A
titleOfInvention Method for preparing tropine through biological enzyme catalysis
abstract A method for preparing tropine by using biological enzyme catalysis, which belongs to the technical field of preparation of medical intermediates. According to the reaction, water is used as a solvent, and the conventional Pd heavy metal catalyst is replaced by the biological enzyme TR-I, so that the reaction scheme is optimized, the reaction selectivity is greatly improved, and the recycling times of the reaction catalyst are increased. The selectivity is greatly improved, secondary recrystallization is not needed, the product loss is reduced, and the yield is improved; meanwhile, the problems of environmental pollution and operation danger caused by heavy metal generated in the reaction are solved. The optimized synthesis route has the advantages of high yield, low cost, high safety factor, energy saving and the like, and meets the requirements of modern chemical production of green reaction.
priorityDate 2021-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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