| abstract |
The invention discloses a preparation method and an intermediate of a 2-cyano-3-amino acrylate compound. The method comprises the following steps: reacting a compound (I) with a compound (II) in an organic solvent under an alkaline condition to obtain an intermediate (III); (2) reacting the intermediate (III) with an alkylating reagent under alkaline conditions to obtain an Intermediate (IV); (3) ammoniating the Intermediate (IV) to obtain the 2-cyano-3-amino acrylic ester compound. The preparation process is simple, the generation of three wastes is reduced, the raw medicine with the content not less than 95 percent is obtained, the total yield is more than 85 percent, all the raw materials are common and easy to obtain, the reaction condition is mild, and the high-temperature and high-pressure operation is not needed. |