http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113845405-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C37-045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C245-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C37-045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C39-24 |
| filingDate | 2021-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113845405-B |
| titleOfInvention | A method for continuously synthesizing diflufenamide intermediate m-trifluoromethylphenol |
| abstract | The invention discloses a method for continuously synthesizing m-trifluoromethylphenol, an intermediate of diflufenamide, (1): adding sulfuric acid aqueous solution and m-trifluoromethylaniline into a mixer continuously in a certain proportion to generate sulfate; (2): the sulfuric acid solution of sulfate solution and nitrosyl sulfuric acid is added in the continuous dynamic tubular reactor according to a certain ratio, carries out diazotization reaction, obtains the solution of diazonium salt; (3): will (2) The solution of the obtained diazonium salt is continuously sprayed into the hydrolysis tank for hydrolysis reaction, and the mixture of m-trifluoromethylphenol vapor and water vapor enters the oil-water separator after condensation, and the phases are separated to obtain m-trifluoromethylphenol organic phase, water phase After extraction with a non-polar solvent, the organic phases were combined to obtain m-trifluoromethylphenol solution. The continuous preparation method can shorten the reaction time, improve the production efficiency and reduce the safety risk, and the yield can reach more than 95% and the purity can reach more than 99.5%. |
| priorityDate | 2021-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.