| abstract |
The present invention provides a preparation method of degradable polymer microspheres. The preparation method comprises the following steps: dissolving a degradable polymer raw material in an organic solvent to obtain a first solution; In the second solution of acid and hyaluronidase, a microsphere reaction system is obtained; the organic solvent in the microsphere reaction system is removed to obtain a crude degradable polymer microsphere; the crude polymer microsphere is washed and dried , to obtain degradable polymer microspheres. In the present invention, the organic solvent in which the degradable polymer is dissolved is atomized by ultrasonic waves to form oil droplets with a relatively uniform diameter, and the hyaluronic acid solution is creatively used as the continuous phase, avoiding traditional emulsifiers such as Tween, polyvinyl alcohol, The use of polyvinylpyrrolidone, etc., and the addition of hyaluronidase can degrade hyaluronic acid while volatile organic reagents, gradually reduce the viscosity of the continuous phase, and the suspension does not foam and is easy to wash. |