| abstract |
The invention belongs to the field of organic chemical ligands, in particular to a cinchona base ligand having the structure of general formula I or its tautomer, enantiomer and diastereomer: Wherein, R 1 is selected from alkyl, alkenyl, -CH=CHPh, R 2 is selected from hydrogen, alkyl, phenyl, substituted phenyl, and R is selected from substituted phenyl. The invention also discloses the preparation method and application of the cinchonaine ligand. The ligand of the present invention has advantages in both stereoselectivity and reaction efficiency, and can obtain higher ee value and yield in asymmetric reactions. |