| abstract |
The invention belongs to the field of biomedicine, and discloses a cannabidiol-containing nanocomposite material and a preparation method and application thereof. The composite material comprises a chitosan film layer and cannabidiol-loaded Prussian blue nanoparticles. The chitosan film layer is wrapped on cannabidiol-loaded Prussian blue nanoparticles, and the nanocomposite is positively charged. The preparation method comprises the following steps: reacting potassium ferricyanide and polyvinylpyrrolidone to obtain Prussian blue, then obtaining hollow Prussian blue by acid corrosion, loading cannabidiol on the hollow Prussian blue to obtain drug-loading nanoparticles, and electrostatically adsorbing the drug-loading nanoparticles on the hollow Prussian blue. The nanoparticles are coated with a chitosan layer. The nano-composite material of the invention has good antibacterial effect, is not easy to cause bacteria to develop drug resistance, has good stability and dispersibility, low toxicity, simple preparation method, short time consumption, easy scale, and can be used for preparing photothermal antibacterial drugs or Multifunctional treatment of wound infection. |