| abstract |
A non-injectable or instillable formulation has been developed in the form of capsules, tablets, oral suspensions, enemas, and rectal or vaginal suppositories or inserts comprising Self-assembled hydrogels formed from gelling factors such as Food and Drug Administration (Food and Drug Administration) Generally Regarded as Safe (GRAS) compounds such as ascorbyl palmitate. In a preferred embodiment, the formulation contains an anti-inflammatory, anti-infective or other therapeutic, prophylactic or diagnostic agent that can be administered orally, This is particularly the case when it is preferred that the blood level of the agent is lower relative to the tissue level. In the most preferred formulations, the composition contains nanostructured tacrolimus-loaded ascorbyl palmitate gel microfibrils ("hydrogels"). |