| abstract |
A medication package comprising: a polymeric wall having an interior surface and an exterior surface; and a tie coating of SiOxCy and/or a barrier coating of SiOxCy and/or a protective coating of SiOxCy on said inner surface. The wall may be formed into the vessel by laser welding. The package can be, for example, a rigid container, a bioprocessing bag, or a transfer bag, wherein the coating provides improved barrier properties and/or effectively blocks extractables/leachables from the substrate and any coating thereon, and the coating is capable of retaining its desired characteristics described herein under tensile/elongation conditions. The pouch or rigid container can be used throughout the CAR T cell manufacturing/therapy. A method of handling a coated package includes restricting stretching of the package. Methods of monitoring or controlling the internal pressure of the coated package are also described. |