http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113789171-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1037 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6486 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-33 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-02 |
| filingDate | 2021-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113789171-B |
| titleOfInvention | Complex for in vivo detection of β-amyloid, preparation method and application thereof |
| abstract | The invention relates to the technical field of biomedicine, and specifically discloses a complex for in vivo detection of beta-amyloid and a preparation method and application thereof. The complex for in vivo detection of β-amyloid provided by the present invention is composed of mesoporous silicon modified by at least one of lactoferrin, transferrin and other types of transport receptors and small molecule probes doped. ; the small molecule probe is selected from at least one of Thioflavin T and SZIs. The invention pioneers the use of SZIs small molecule probes for the detection of β-amyloid, and proposes a general strategy for nanocomplexes of modified mesoporous silicon/small molecule probes to assist small molecules such as SZIs and ThT The high efficiency of the probes across the blood-brain barrier makes it possible to use these small-molecule probes for in vivo real-time imaging of β-amyloid in the brain. |
| priorityDate | 2021-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 115.