| abstract |
The invention provides a human interleukin 2-polyethylene glycol conjugate and its application. The human interleukin 2-polyethylene glycol conjugate provided by the present invention comprises recombinant human interleukin 2 containing at least one unnatural amino acid and PEG coupled to the at least one unnatural amino acid, and the unnatural amino acid Amino acid is a compound with a carbonyl end group having a structure as shown in formula (I) or its enantiomer, and the PEG is coupled to the compound by forming an oxime bond with the PEG containing a hydroxylamine end group. at least one unnatural amino acid. The human interleukin-2-polyethylene glycol conjugate provided by the present invention can be used alone or in combination with other anti-tumor drugs for the treatment of solid tumors, blood tumors and other diseases, |