http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113773240-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-22 |
| filingDate | 2021-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113773240-B |
| titleOfInvention | Preparation method of gemifloxacin side chain compound |
| abstract | The invention discloses a preparation method of gemifloxacin side chain compound. The preparation method comprises the following steps: s1, reacting 1-N-tert-butyloxycarbonyl-4-cyano-3-pyrrolidone with methoxyamine hydrochloride to obtain a compound shown as a formula (V); s2, carrying out hydrogenation reduction reaction on the compound shown in the formula (V) in an inert atmosphere at the temperature of 10-50 ℃ in the presence of palladium carbon for 1-3 h under the hydrogen atmosphere of 0.1-0.5 Mpa; adding Boc anhydride, and continuously carrying out hydrogenation reduction reaction for 4-8 h at 10-50 ℃ and 0.1-0.5 Mpa to obtain a compound shown in a formula (VI); and (3) reacting the compound shown in the formula (VI) and S3 with acid to remove a protecting group, thus obtaining the gemifloxacin side chain compound shown in the formula (I). The preparation method has simple process, very mild reaction conditions and easy realization; (2) the raw materials are low in price and low in cost; (3) a new and effective synthesis process route of the gemifloxacin side chain is created. |
| priorityDate | 2021-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.