| abstract |
The invention discloses a valsartan dispersion and a preparation method and particle size determination method thereof. The valsartan dispersion includes isoparaffin solvent and valsartan. The valsartan dispersion in the present invention has good dispersion effect. , the dispersion is stable, the secondary aggregation phenomenon will not occur, the problem in the prior art that the valsartan particles cannot be fully dispersed due to the strong electrostatic adsorption of valsartan particles is solved, and the use of organic compounds with high cost and large toxic and side effects is avoided at the same time. Solvents or slightly toxic surfactants such as dodecyl sulfate. The preparation method of the valsartan dispersion in the present invention is simple, easy to operate, has good reproducibility, and does not require equipment. The selection of ultrasonic time and ultrasonic frequency in the preparation method is very important. If the ultrasonic time and ultrasonic frequency do not meet the requirements, the valsartan particles will be aggregated. If the ultrasonic time and ultrasonic frequency exceed the ultrasonic time and ultrasonic frequency in the present invention. Ultrasound frequency, the valsartan granules are easy to rupture. |