| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_216219f3f802527da70eeb6113f6cbf1 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54386
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57426
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6839
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-531
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-533 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-533
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-531
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate |
2020-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c2b4a592f0716971eb2c923596f461a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7874daefded88dc2fe6b6a79d35fd41b |
| publicationDate |
2021-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113759114-A |
| titleOfInvention |
Method for researching AML exosome resistance effect and mechanism on AML chemotherapy |
| abstract |
The invention relates to a method for researching the resistance effect and mechanism of AML exosome to AML chemotherapy, which comprises the following steps: 1) in vivo and in vitro experiments prove that JAK/STAT3 signal channels regulate the effect of MSC on the resistance of AML cell chemotherapy; 2) experiments prove that the exosome from AML has the up-regulation effect on JAK/STAT3 signal channels in MSCs and the resistance effect on AML cell chemotherapy in mediated MSC; 3) the mechanism of action of an AML-derived exosome for regulating a JAK/STAT3 signal pathway is researched through an in vitro experiment. The invention has the advantages that: by researching the JAK/STAT3 signal pathway and the action mechanism of exosome in AML chemotherapy resistance, a new treatment target point is provided for clinically treating AML, and the method has important clinical significance. |
| priorityDate |
2020-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |