| abstract |
The invention discloses asymmetric hydrogen aryl amination, hydrogen alkyl amination and hydrogen amidation of olefins by using a combination of nickel and a ligand to catalyze the realization, and belongs to the fields of organic chemistry and medicinal chemistry. In the present invention, under the action of metal nickel source, chiral ligand, hydrogen source, additives, etc., olefin and different amine sources are reacted in organic solvent, and a series of chirality can be obtained with excellent enantioselectivity and good yield. Amine compounds. The invention uses cheap transition metal nickel as a catalyst, and uses simple and readily available olefin and amine sources as raw materials, with mild and simple conditions, good functional group compatibility, and simple operation. |