http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113754630-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D339-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D339-04 |
| filingDate | 2021-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113754630-B |
| titleOfInvention | Synthetic method of alpha-lipoic acid |
| abstract | A method for synthesizing alpha-lipoic acid, belonging to the technical field of pharmaceutical chemistry synthesis. Firstly, N- (4-bromobutyl) phthalimide is taken as a raw material to prepare a zinc bromide intermediate, then the zinc bromide intermediate reacts with 3- { [2- (trimethylsilyl) ethoxy ] methoxy } propionyl chloride to generate an intermediate-1, and the intermediate-2 is obtained through a hydrazinolysis reaction; which is subjected to iodination reaction to obtain an intermediate-3; carrying out pressurized carbonyl insertion reaction on the intermediate-3 to obtain an intermediate-4; carrying out reduction reaction on the intermediate-4 to obtain an intermediate-5; carrying out deprotection reaction on the intermediate-5 under the action of tetrabutylammonium fluoride to obtain an intermediate-6; carrying out chlorination reaction on the intermediate-6 to obtain an intermediate-7; finally, alpha-lipoic acid is obtained through sulfhydrylation reaction and oxidation ring closing. The method has the advantages of mild process conditions, easily obtained raw materials, high purity of the intermediate and the final product, contribution to quality control and improvement of the raw material medicine of the final product, and suitability for industrial production. |
| priorityDate | 2021-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 154.