| abstract |
The invention provides an application of miRNA-15A in treating high-expression KIF3B tumor. In particular discloses an application of miRNA, a precursor pre-miRNA thereof or a derivative thereof in preparing a medicament for inhibiting the proliferation of a tumor cell with high expression of KIF3B and promoting the apoptosis of the tumor cell with high expression of KIF3B, or in preparing a medicament for reducing the proliferation, migration, invasion and clonogenic capacity of the tumor cell with high expression of KIF 3B; the nucleotide sequence of the miRNA is shown in SEQ ID No. 1. The tumor cells highly expressing KIF3B are selected from triple negative breast cancers. The invention proves that the high expression of KIF3B is related to the proliferation, infection, migration, invasion and clonogenic capacity of triple negative breast cancer for the first time, and proves that the reduction of the expression of KIF3B can realize the inhibition of the proliferation, infection, migration, invasion and clonogenic capacity of triple negative breast cancer. |